AGING GRACEFULLY: Brain and joint health are important to maintain as we get older. SAMe is able to cross the blood-brain barrier, impacting the synthesis and activation of various brain chemicals, including neurotransmitters, which affect our overall mental health. Also, it plays a critical role in cartilage formation, and, therefore, supports joint health. POTENT ANTIOXIDANT ACTIVITY: SAMethylate Plus contains superoxide dismutase (SOD) and catalase. SOD is an enzyme that Maintains cellular health & function and provides antioxidant protection against cellular damage from free radicals and environmental toxins. Catalase in an enzyme that converts hydrogen peroxide into oxygen and water, also showing strong antioxidant properties. WHO WE ARE: Biotics Research was the first company to introduce a natural form of CoQ10 as a dietary supplement into the US market in 1979. We have revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. We drive advancement by focusing our initiatives on research, natural effectiveness, product safety, efficacy, unparalleled quality control and continuing innovation. WHO WE ARE: We are Biotics Research. We have revolutionized the nutritional supplement industry by utilizing “The Best of Science and Nature”. We drive advancement by focusing our initiatives on research, natural effectiveness, product safety, efficacy, unparalleled quality control and continuing innovation. QUALITY MADE IN THE USA: We produce tablets, capsules, powders and liquids in our Rosenberg, Texas, Texas Department of Health licensed, GMP-certified production and laboratory facility. Our products are tested in our state-of-the-art laboratory to ensure their safety, efficacy, and purity, and MetabolicBiome Plus, like all Biotics Research products, is Gluten Free!